DESCRIPTION: AMOXICILLIN IS A SEMI-SYNTHETIC DERIVATIVE OF PENICILLIN, STABLE IN ACIDS, WITH A WIDE SPECTRUM OF EFFECT AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA.SIMILAR TO OTHER PENICILLINS, THE MECHANISM OF ITS EFFECT IS BASED ON A BLOCKAGE OF THE SYNTHESIS OF THE CELL WALL IN BACTERIA. THE ANTIBIOTIC IS BOUND TO A SPECIAL BINDING PROTEIN, THE SYNTHESIS OF THE CELL WALL IS INHIBITED BY THE BLOCKAGE OF SYNTHESIS OF PEPTIDOGLYCAN, AND AUTOLYTIC ENZYMES ARE ACTIVATED IN THE CELL WALL RESULTING IN WALL LESIONS AND CELL DEATH.ANTIBACTERIAL IMPACT OF AMOXICILLIN INCLUDES A WIDE RANGE OF MICROBES SUCH AS STAPHYLOCOCCUS SPP., STREPTOCOCCUS SPP. (THIS DOES NOT CAUSE PENICILLIOSIS), HAEMOPHILUS SPP., CORYNEBACTERIUM SPP., BRUCELLA SPP., SHIGELLA SPP., FUSIFORMIS SPP., CLOSTRIDIA SPP., STEPTOCOCCUS FAECALIS, SALMONELA SPP., E. COLI, PROTEUM MYRABILIS, PROTEUS VULGARIS (MIC 10 ?G/ML). THE STRAINS WITH NO SENSITIVE REACTIONS ARE THOSE PROVOKING PENICILLIOSIS SUCH AS STAPHYLOCOCCUS, KLEPSIELLA, PSEUDOMONAS AND PROTEUS. AMOXICILLIN IS ABSORBED QUICKLY IF ADMINISTERED I.M. AND S.C. AND MAXIMUM PLASMATIC LEVELS ARE RECORDED (WITHIN 1 – 3 HOURS). ACTIVE VALUES OF THE ACTIVE SUBSTANCE PERSIST IN BLOOD FOR 48 HOURS AT LEAST. AMOXICILLIN QUICKLY PENETRATES INTO TISSUES AND LIQUIDS. PARTICULARLY HIGH CONCENTRATION LEVELS ARE OBSERVED IN URINE, BILE, KIDNEYS AND LIVERS. THIS PREPARATION IS TRANSFERRED VIA PLACENTA. THE DETECTED CONCENTRATION VALUES ARE HIGHER COMPARED TO MATERNAL BLOOD LEVELS. AMOXICILLIN CAN BE ELIMINATED IN ITS UNCHANGED FROM VIA KIDNEYS. IF AMOXICILLIN IS ELIMINATED IN MILK DURING THE LACTATION PERIOD, DIFFERENT ANIMAL SPECIES SHOULD BE CONSIDERED. Each ml contains:- Amoxicillin Trihydrate eq. to Amoxicillin.......120mg Colistine Sulphate.......300,000 IU (As per Innovator's Specification)*