Pronil injection is the combination of diminazine which acts as anti-trypanosomiasis agent and antipyrine which as analgesic, antipyretic agent. The combination provides effective treatment against Trypanosomes and babesia in cattle, sheep, horses, camels and dogs. Diminazine is a diamidine derivative which gives a high trypanocidal effect against T.vivax, T-congolase, T-brucei, Its spectrum is wide due to which is equally effective against Babesia like babesia bovis, B-big emina, B-motasi, B-canis and Piroplasmaalso. Antipyrine a pyrazolone derivative has powerful analgesic, antipyretic and anti-inflammatory action. It is of great value as adjunct to primary therapy, septic or endotoxic shock describes the spectrum of changes found in an animal suffering trypanosomiasis. Trypanosomosis caused by Trypanosoma congolense, T. vivax, T.brucei. PiropIasmosis caused by Babesiabovis, B. bigemina, B. ovis, B. motasi, B. canis. Theileriosis caused by Theileriaannulata.