ovine Ketosis. Predef 2X sterile aqueous suspension, by its gluconeogenic and glycogen deposition activity, is an effective and valuable treatment for the endocrine and metabolic imbalance of primary bovine ketosis. The stresses of parturition and high milk production predispose the dairy cow to this condition. This adrenal steroid causes a prompt physiological effect, with blood glucose levels returning to normal or above within 8 to 24 hours following injection. There is a decrease in circulating eosinophils, followed by a reduction in blood and urine ketones. Usually the general attitude of the cow is much improved, appetite returns, and milk production rises to previous levels within 3 to 5 days. In secondary bovine ketosis, where the condition is complicated by pneumonia, mastitis, endometritis, traumatic gastritis, etc., Predef 2X sterile aqueous suspension should be used concurrently with proper local and parenteral antibacterial therapy, infusion solutions, and other accepted treatments for the primary conditions. Milk Fever. Predef 2X sterile aqueous suspension has been found to be excellent supportive therapy in the treatment of the stress associated with parturient paresis. It should be given intramuscularly, before or after the administration of the calcium infusion solutions commonly employed in treating the disease. Predef 2X sterile aqueous suspension is not to be added to the infusion solutions.